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Published on: January 30, 2014

Research Trends and Progress of Microglia in Parkinson's Disease: A Bibliometric Analysis

Ye Dou1, Qiong Wu2, Kuo Gao1

  • 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China.

Current Neuropharmacology
|July 16, 2026
PubMed
Abstract

Insights

This bibliometric analysis reveals key research trends in microglia and Parkinson's disease. Emerging hotspots include autophagy, the NLRP3 inflammasome, and gut microbiota, guiding future investigations.

Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Microglia are increasingly recognized for their significant role in Parkinson's disease pathogenesis and progression.
  • Bibliometric analysis is employed to map the research landscape concerning microglia and Parkinson's disease.

Purpose of the Study:

  • To elucidate focal areas and emerging hotspots in Parkinson's disease research involving microglia.
  • To systematically map the current research landscape and guide future investigations.

Main Methods:

  • A systematic literature search was conducted in the Web of Science Core Collection (WoSCC) up to December 31, 2025.
  • Bibliometric visualization and network analysis were performed using CiteSpace and VOSviewer.

Main Results:

  • Analysis of 7,371 articles revealed fluctuating publication growth since 1988, with the USA as the leading contributor.
  • Key institutions include the National Institutes of Health, and leading journals are Journal of Neuroinflammation and Journal of Neuroscience.
  • Prominent researchers include Hong, Jau-Shyong, and McGeer, P.L., with "Parkinson's disease", "Microglia", and "Neuroinflammation" as top keywords.

Conclusions:

  • Research on microglia and Parkinson's disease is expanding, emphasizing the need for greater international and institutional collaboration.
  • Early research focused on microglial inflammatory mechanisms in dopaminergic neuron damage.
  • Current research hotspots include autophagy, the NLRP3 inflammasome, and the gut microbiota, offering new therapeutic avenues.
Keywords:
CiteSpaceParkinson’s diseaseVOSviewerbibliometric analysismicrogliavisualization

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