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Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Related Experiment Video

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Direct Mouse Trauma/Burn Model of Heterotopic Ossification
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Machine Learning-Based Text Processing Reveals Research Trends in Heterotopic Ossification.

Yangbai Sun1,2, Qinyuan Zhu3, Chaoran Yu4

  • 1Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, sjtu.edu.cn.

Analytical Cellular Pathology (Amsterdam)
|July 16, 2026
PubMed
Summary

This study analyzed 4722 publications on heterotopic ossification (HO), identifying key research trends and influential contributors. Cell differentiation and bone formation topics have dominated recent HO research.

Keywords:
Web of Sciencebibliometric analysisheterotopic ossificationmachine learning

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Area of Science:

  • Pathological bone formation research
  • Bibliometric analysis of scientific literature
  • Machine learning applications in biomedical research

Background:

  • Heterotopic ossification (HO) is a significant area of research in pathological bone formation.
  • Despite advancements, a complete understanding of HO mechanisms and clinical progression is lacking.

Purpose of the Study:

  • To conduct an extensive text processing analysis of heterotopic ossification research.
  • To identify key topics, influential authors, and research trends in the field of HO.
  • To provide insights and direction for future HO research.

Main Methods:

  • Bibliometric analysis of 4722 publications from the Web of Science Core Collection.
  • Latent Dirichlet Allocation (LDA) machine learning for topic modeling.
  • Network analysis of institutions and authors, citation analysis, and developmental timeline visualization.

Main Results:

  • USA, China, and Germany are leading countries in HO research, with Germany and China showing high citation impact.
  • Key terms include "fibrodysplasia ossificans progressive," "complications," and "total hip arthroplasty."
  • LDA identified 16 topics, with "cell bone express differentiation and formation" being dominant in the last decade. Shanghai Jiao Tong University and Wilderness Spine Serv were highlighted for specific research strengths.

Conclusions:

  • This study represents the most comprehensive text analysis of HO research to date.
  • The findings offer valuable insights into the current landscape and future directions for HO research.
  • Identified trends and dominant topics provide a roadmap for researchers in pathological bone formation.