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Are We Measuring What Matters? The Surrogate Trap in Endodontics
Emmanuel J N L Silva1,2,3, Gustavo De-Deus1, Erick M Souza4
1Department of Endodontics, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil.
International Endodontic Journal
|July 16, 2026
Summary
Surrogate endpoints in endodontic research offer practical benefits but don't always reflect patient-centered outcomes like tooth survival. Future research should integrate patient-reported outcomes for a holistic view of treatment success.
Area of Science:
- Endodontics
- Dental Research
- Clinical Trials
Background:
- Surrogate endpoints are crucial for evaluating endodontic treatments efficiently.
- However, they measure indirect processes, not direct patient outcomes like tooth survival or quality of life.
