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Related Experiment Video

Updated: Jul 17, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

Collaborative care treatment for major depressive disorder.

Chase Walker¹, Virna Little², Jennifer Lyons³

¹JG Research and Evaluation, Bozeman, MT, United States.

Frontiers in Psychiatry

|July 16, 2026

Summary

The Collaborative Care Model (CoCM) shows effectiveness for severe Major Depressive Disorder (MDD), though severe cases may require more intensive care. Factors like insurance and comorbidities influence treatment outcomes.

Keywords:

collaborative care collaborative care delivery depression major depressive disorder mental health

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Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

Published on: July 7, 2023

Area of Science:

Behavioral Health
Psychiatry
Health Services Research

Background:

Major Depressive Disorder (MDD) presents significant treatment challenges, especially in severe cases.
The Collaborative Care Model (CoCM) is established for moderate depression but its efficacy in severe MDD requires further investigation.
Concert Health data provides a large cohort for analyzing CoCM effectiveness across depression severity spectrums.

Purpose of the Study:

To evaluate the impact of CoCM on depression treatment outcomes across all MDD severity levels.
To identify patient characteristics and treatment factors associated with treatment response and remission in MDD patients.
To specifically assess CoCM effectiveness for patients with severe depression.

Main Methods:

Analysis of 30,162 closed patient treatment episodes at Concert Health (2018-2025).
Comparison of effect sizes for PHQ-9 score changes between baseline and final assessments across depression severity levels.
Logistic regression used to identify predictors of treatment response and remission.

Main Results:

Patients with severe depression had slightly lower odds of response (OR: 0.93) compared to those with moderate depression.
Insurance type, suicide risk, anxiety comorbidity, and patient engagement (touchpoints) significantly impacted response and remission.
CoCM demonstrated potential effectiveness for severe depression patients.

Conclusions:

CoCM may be effective for achieving treatment response in severe depression.
Patients with severe depression, Medicaid insurance, or comorbidities like anxiety and suicide risk may require enhanced care team engagement.
Tailored interventions within CoCM are crucial for optimizing outcomes in complex MDD cases.