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Case Report: Allogeneic hematopoietic stem cell transplantation in a patient with acute myeloid leukemia and

Johanna Lepek1, Celine Lugnier1, Marie von Lilienfeld-Toal1,2

  • 1Department of Hematology, Oncology, Stem Cell Transplantation and Cellular Therapy, Knappschaft Kliniken Universitätsklinikum Bochum, Ruhr University, Bochum, Germany.

Frontiers in Oncology
|July 16, 2026
PubMed

In immunocompromised patients the Hepatitis E Virus (HEV) can lead to severe liver injury and possible liver failure. This case report describes a patient with acute myeloid leukemia in urgent need of allogeneic hematopoietic stem cell transplantation (HSCT), having symptomatic HEV infection. Prior to allogeneic HSCT, therapy with ribavirin was initiated. Urgent allogeneic HSCT was successfully performed despite persistence of HEV, with continuous ribavirin treatment during transplantation. Data regarding management of patients with HEV infection in need for HSCT is scarce. This case illustrates the feasibility of HSCT in patients with ongoing HEV-infection under continuous therapy with ribavirin.

Keywords:
AMLHSCT, hematopoietic stem cell transplantacute myeloid leukemiaallogeneic stem cell transplantationhepatitis E

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