Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 17, 2026

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

Structural Gains Without Symptomatic Benefit After Microfracture During High Tibial Osteotomy.

Do Kyung Lee1, Joon Ho Wang2,3

  • 1Department of Orthopedic Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.

Orthopaedic Journal of Sports Medicine
|July 16, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D bioprinting of functional meniscus constructs with anisotropic properties using meniscus-derived bioink for knee meniscus regeneration.

Biofabrication·2026
Same author

Rotational Subluxation Patterns on Stress Radiography and Clinical Relevance in PCL-Deficient Knees: A 2D-3D Registration Study.

Orthopaedic journal of sports medicine·2026
Same author

Magnetic Resonance Neurography in Spontaneous Radial Neuropathy: An Unexpectedly High Rate of Nerve Constriction.

Muscle & nerve·2026
Same author

Increased Graft Diameter and Quadrupled Versus Tripled Hamstring Tendon Autograft Are Associated With Improved Graft Survival in Double-Bundle Anterior Cruciate Ligament Reconstruction.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026
Same author

Validity of DEXA-Derived Thigh Muscle Quantification Against AI-Assisted CT: Inter-Limb Asymmetry Provides Superior Agreement over Absolute Values.

Journal of clinical medicine·2026
Same author

Short Femoral In-Tunnel Graft Length Does Not Compromise Graft Healing and Clinical Outcomes After Combined Anterior Cruciate Ligament and Anterolateral Ligament Reconstruction Using Hamstring Autograft.

The American journal of sports medicine·2026

Microfracture (MFx) during high tibial osteotomy (HTO) improved cartilage regeneration but did not enhance patient outcomes. MFx was linked to lower knee function scores, indicating a disconnect between structural repair and symptom relief in knee osteoarthritis.

Area of Science:

  • Orthopedic surgery
  • Regenerative medicine
  • Biomechanical engineering

Background:

  • High tibial osteotomy (HTO) is used to realign knee mechanics and reduce medial compartment overload in osteoarthritis.
  • Microfracture (MFx) is often combined with HTO to promote cartilage repair, but its benefit in degenerative joints is unclear.
  • Emerging evidence suggests a discordance between structural cartilage changes and patient symptoms.

Purpose of the Study:

  • To assess if MFx during HTO improves cartilage regeneration and patient-reported outcomes.
  • To determine if structural improvements after MFx correlate with symptomatic benefits.
  • Hypothesis: MFx enhances cartilage regeneration and leads to superior clinical outcomes compared to HTO alone.

Main Methods:

  • A cohort study (Level 3 evidence) included 62 patients undergoing navigation-assisted HTO with second-look arthroscopy at 2 years.
Keywords:
cartilage regenerationclinical outcomehigh tibial osteotomymicrofractureosteoarthritis

Related Experiment Videos

Last Updated: Jul 17, 2026

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

  • Patients were divided into HTO alone (n=30) and HTO with MFx (n=32) groups.
  • Cartilage status (ICRS) and clinical outcomes (IKDC subjective score) were evaluated at 2 years.

    • Main Results:

    • Cartilage improvement was observed in 62.5% of the MFx group versus 33.3% in the HTO-alone group (P=.04).
    • Despite better structural healing, no significant difference in 2-year IKDC scores was found between groups (50.6 vs 55.2, P=.26).
    • MFx was an independent negative predictor of IKDC score (β=-14.4, P=.01), and cartilage changes did not correlate with symptom improvement (ρ=-0.18, P=.14).

    Conclusions:

    • MFx during HTO improved cartilage morphology but did not lead to superior clinical outcomes.
    • MFx was associated with significantly lower adjusted IKDC scores.
    • Structural improvement after MFx did not correlate with symptomatic benefit, highlighting structure-symptom discordance.