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Related Experiment Video

Updated: Jul 21, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Colonic pleomorphic undifferentiated sarcoma with a leukemoid reaction: case report.

Ruizhi Wang1, Tao Shan2, Dong Mu1

  • 1Department of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, China.

Frontiers in Medicine
|July 16, 2026
PubMed
Summary

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Primary colonic undifferentiated pleomorphic sarcoma (UPS) can cause a leukemoid reaction, mimicking blood cancer. Surgical removal of the tumor (UPS) reversed this reaction, highlighting a paraneoplastic syndrome.

Area of Science:

  • Oncology
  • Gastroenterology
  • Hematology

Background:

  • Undifferentiated pleomorphic sarcoma (UPS) is a rare and aggressive mesenchymal tumor.
  • Primary colonic UPS is exceptionally rare, and its association with a leukemoid reaction is even rarer.
  • This paraneoplastic syndrome can mimic hematologic malignancy, potentially delaying diagnosis and treatment.
Keywords:
case reportcolonleukemoid reactionmalignant fibrous histiocytomaundifferentiated pleomorphic sarcoma

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