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Published on: April 11, 2018
Colonic pleomorphic undifferentiated sarcoma with a leukemoid reaction: case report
Ruizhi Wang1, Tao Shan2, Dong Mu1
1Department of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, China.
Frontiers in Medicine
|July 16, 2026
Summary
Primary colonic undifferentiated pleomorphic sarcoma (UPS) can cause a leukemoid reaction, mimicking blood cancer. Surgical removal of the tumor (UPS) reversed this reaction, highlighting a paraneoplastic syndrome.
Area of Science:
- Oncology
- Gastroenterology
- Hematology
Background:
- Undifferentiated pleomorphic sarcoma (UPS) is a rare and aggressive mesenchymal tumor.
- Primary colonic UPS is exceptionally rare, and its association with a leukemoid reaction is even rarer.
- This paraneoplastic syndrome can mimic hematologic malignancy, potentially delaying diagnosis and treatment.
