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Updated: Jul 17, 2026

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

Published on: March 20, 2017

Focusing scattered light through live tissue with channel-selected wavefront shaping.

Conger Jia¹, Yuecheng Shen^1,2, Zhengyang Wang³

¹State Key Laboratory of Precision Spectroscopy, School of Physics, East China Normal University, Shanghai 200241, China.

Biomedical Optics Express

|July 16, 2026

Summary

Channel-selected wavefront shaping (CS-WS) improves deep-tissue focusing in dynamic biological environments by selectively optimizing slow-varying scattering channels, outperforming conventional methods.

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Area of Science:

Biomedical Optics
Optical Engineering

Background:

Wavefront shaping (WS) enables deep-tissue optical focusing but struggles with dynamic scattering in vivo.
Physiological processes like blood flow cause rapid scattering changes, degrading conventional WS performance.

Purpose of the Study:

To develop a novel wavefront shaping strategy for robust deep-tissue focusing in dynamic biological tissues.
To address the limitations of conventional WS in adapting to fast decorrelation caused by blood flow.

Main Methods:

Proposed a channel-selected WS (CS-WS) strategy classifying scattering channels by decorrelation speed.
Optimized slow-varying channels while deactivating fast-varying ones (e.g., blood vessels).
Validated CS-WS in vivo on mouse ears using a 4 ms iteration time closed-loop system.

Main Results:

CS-WS demonstrated 38% faster convergence (398 vs. 642 iterations) compared to conventional WS.
Achieved 27% higher focal enhancement (14.85 vs. 11.68) than conventional full-aperture WS.
Successfully adapted to dynamic scattering environments in live animal models.

Conclusions:

CS-WS offers a practical and efficient solution for deep-tissue optical focusing in dynamic in vivo scenarios.
This approach enhances focusing efficiency by intelligently managing scattering channels.
CS-WS has broad potential for advancing biomedical optics and in vivo imaging.