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Updated: Jul 17, 2026
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Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping
Published on: March 20, 2017
Focusing scattered light through live tissue with channel-selected wavefront shaping
Conger Jia1, Yuecheng Shen1,2, Zhengyang Wang3
1State Key Laboratory of Precision Spectroscopy, School of Physics, East China Normal University, Shanghai 200241, China.
Biomedical Optics Express
|July 16, 2026
Summary
Channel-selected wavefront shaping (CS-WS) improves deep-tissue focusing in dynamic biological environments by selectively optimizing slow-varying scattering channels, outperforming conventional methods.
Area of Science:
- Biomedical Optics
- Optical Engineering
Background:
- Wavefront shaping (WS) enables deep-tissue optical focusing but struggles with dynamic scattering in vivo.
- Physiological processes like blood flow cause rapid scattering changes, degrading conventional WS performance.
Purpose of the Study:
- To develop a novel wavefront shaping strategy for robust deep-tissue focusing in dynamic biological tissues.
- To address the limitations of conventional WS in adapting to fast decorrelation caused by blood flow.
Main Methods:
- Proposed a channel-selected WS (CS-WS) strategy classifying scattering channels by decorrelation speed.
- Optimized slow-varying channels while deactivating fast-varying ones (e.g., blood vessels).
- Validated CS-WS in vivo on mouse ears using a 4 ms iteration time closed-loop system.
Main Results:
- CS-WS demonstrated 38% faster convergence (398 vs. 642 iterations) compared to conventional WS.
- Achieved 27% higher focal enhancement (14.85 vs. 11.68) than conventional full-aperture WS.
- Successfully adapted to dynamic scattering environments in live animal models.
Conclusions:
- CS-WS offers a practical and efficient solution for deep-tissue optical focusing in dynamic in vivo scenarios.
- This approach enhances focusing efficiency by intelligently managing scattering channels.
- CS-WS has broad potential for advancing biomedical optics and in vivo imaging.
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