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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

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Related Experiment Video

Updated: Jul 17, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Clostridioides difficile Infection-Associated Functional Bowel Disorder: A Three-Year Cohort Study.

Garrison P Wright1, Nina Gu1, Natalie V S Pham1

  • 1Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.

Open Forum Infectious Diseases
|July 16, 2026
PubMed
Summary

Post-infection functional bowel disorders (FBDs) following Clostridioides difficile infection (CDI) are common. Patients with CDI-associated FBD are younger, more often female, and experience persistent gastrointestinal symptoms.

Keywords:
Clostridioides difficile infectionfunctional bowel disordersirritable bowel syndromepostinfectious diarrhea

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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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Published on: December 10, 2016

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Last Updated: Jul 17, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Psychiatry

Background:

  • Recurrent diarrhea is common after Clostridioides difficile infection (CDI), but not always due to disease recurrence.
  • Postinfectious functional bowel disorders (FBDs) can arise after bacterial or viral gastroenteritis.
  • Distinguishing CDI-associated FBD from recurrent CDI is crucial for effective management.

Purpose of the Study:

  • To compare the characteristics of patients diagnosed with CDI-associated FBD.
  • To contrast these patients with those diagnosed with initial or recurrent CDI alone.

Main Methods:

  • Retrospective review of electronic medical records from a Complicated Clostridioides difficile Clinic.
  • Analysis of patient demographics, risk factors, and outcomes.
  • Comparison between patients with CDI-associated FBD and CDI alone.

Main Results:

  • Of 159 patients, 44 (27.7%) had CDI-associated FBD, and 90 (56.6%) had CDI alone.
  • Patients with CDI-associated FBD were younger, more likely female, and had fewer comorbidities.
  • A history of anxiety and depression was more frequent in patients with CDI-associated FBD.
  • At 3 months, patients with FBD had less frequent symptom resolution and more persistent gastrointestinal issues.

Conclusions:

  • CDI-associated FBD is prevalent and may be misdiagnosed as CDI recurrence.
  • This misdiagnosis can lead to incomplete symptom resolution despite treatment.
  • Further research is needed to improve diagnosis and management of CDI-associated FBD.