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Related Experiment Video

Updated: Jul 17, 2026

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

Diffusion tensor imaging in chronic tension-type headache.

M Teepker^1,2, L Vacik¹, A M Hermsen³

¹Department of Neurology, Philipps-University of Marburg, Marburg, Germany.

Frontiers in Pain Research (Lausanne, Switzerland)

|July 16, 2026

Summary

Chronic tension-type headache (CTTH) patients exhibit microstructural brain changes. These alterations in brain regions involved in pain processing may shed light on the pathophysiology of this difficult-to-treat headache disorder.

Keywords:

AD DTI MRI NODDI RD chronic tension-type headache headache microstructural changes

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Last Updated: Jul 17, 2026

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

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Published on: May 7, 2019

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Published on: August 14, 2019

Area of Science:

Neurology
Neuroimaging
Neuroscience

Background:

Tension-type headache (TTH) is the most prevalent primary headache disorder.
Chronic TTH (CTTH) presents significant treatment challenges.
The underlying pathophysiology of CTTH remains poorly understood.

Purpose of the Study:

To investigate microstructural brain changes in CTTH patients.
To elucidate the pathogenesis of CTTH through neuroimaging findings.

Main Methods:

Diffusion Tensor Imaging (DTI) MRI was performed on nine female CTTH patients and ten healthy controls.
Key DTI metrics including Fractional Anisotropy (FA), Axial Diffusivity (AD), Radial Diffusivity (RD), Neurite Density Index (NDI), and Orientation Dispersion Index (ODI) were calculated.

Main Results:

Significant microstructural changes were identified in various brain regions of CTTH patients.
Affected areas include the cerebellum, cingulate gyrus, thalamic radiation, occipital cortex, insular cortex, and frontal/temporal gyri.
Alterations were also observed in association fibers like the superior longitudinal fasciculus.

Conclusions:

CTTH is associated with widespread microstructural brain alterations.
These changes implicate brain regions within the pain matrix and trigeminal system.
Findings suggest a neurobiological basis for CTTH involving altered neural pathways.