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Design, Optimization and Physicochemical Characterization of Pectin-Based Nanoparticles for In Vitro Anticancer
Pournima Sankpal1, Shiom Mane2, Rashmi Pathak3
1Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Palus (M.S.), India.
Current Pharmaceutical Design
|July 16, 2026
Summary
Natural flavonoids rutin and hesperidin were formulated into pectin nanoparticles to improve their anticancer effects. This nanoformulation enhanced solubility and colon-targeting efficiency for potential colorectal cancer therapy.
Area of Science:
- * Pharmaceutical Nanotechnology
- * Cancer Therapeutics
- * Drug Delivery Systems
Background:
- * Cancer is a significant global health challenge.
- * Natural flavonoids like rutin and hesperidin show anticancer potential but suffer from poor solubility and bioavailability.
- * Limited therapeutic efficacy hinders the clinical use of these natural compounds.
Purpose of the Study:
- * To enhance the solubility and colon-targeting efficiency of rutin and hesperidin.
- * To develop pectin-based nanoparticles encapsulating rutin and hesperidin.
- * To evaluate the anticancer potential of the nanoformulation against colon cancer cells.
Main Methods:
- * Preparation of pectin nanoparticles encapsulating rutin and hesperidin using Probe Sonicator/High-Pressure Homogenization (HPH).
- * Characterization of nanoparticles using X-ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), and Transmission Electron Microscopy (TEM).
Main Results:
- * Successful formation of nanoscale particles with desirable morphology and enhanced stability.
- * Nanoformulation demonstrated improved solubility and bioavailability of rutin and hesperidin.
- * Enhanced cytotoxic effects against colon cancer cells were observed.
Conclusions:
- * Pectin-based nanoparticles significantly improved the solubility and anticancer activity of rutin and hesperidin.
- * The developed nanoformulation shows promise as a colon-targeted drug delivery system for colorectal cancer.
- * This approach offers a viable strategy for enhancing the therapeutic application of natural flavonoids in cancer treatment.
