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Leiomyosarcoma First Signaled by Chest Pain: Beyond Angina
Khalid Shakfeh1, Valentin Suma1, Georges El Khoury1
1Division of Cardiology, University of Florida, Jacksonville, Florida, USA.
JACC. Case Reports
|July 16, 2026
Summary
Primary cardiac leiomyosarcoma, a rare malignancy, can mimic benign masses on imaging. Echocardiography is vital alongside cardiac MRI for accurate diagnosis and surgical planning of these uncommon heart tumors.
Area of Science:
- Cardiology
- Oncology
- Radiology
Background:
- Primary malignant cardiac tumors are exceedingly rare, with a prevalence under 0.03%.
- Cardiac leiomyosarcoma is an exceptionally uncommon subtype, rarely manifesting as severe mitral stenosis.
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