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Updated: Aug 6, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
Published on: January 17, 2020
Earth-Abundant 3d Transition Metal-Catalyzed Enantioselective C-H Functionalization
Pu-Fan Qian1, Jia-Heng Hu1, Yan-Xuan Wu1
1State Key Laboratory of Soil Pollution Control and Safety, Department of Chemistry, Zhejiang University, Hangzhou 310058, China.
Earth-abundant 3d transition metals are revolutionizing enantioselective C-H functionalization, enabling complex molecule synthesis. This review highlights advancements, challenges, and solutions in this rapidly evolving field.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Methodology
Background:
- Enantioselective C-H functionalization is a key strategy for synthesizing complex molecules.
- Precious metal catalysts are well-established, but research is shifting towards earth-abundant 3d transition metals.
- 3d transition metals offer unique properties and reactivity profiles for C-H functionalization.
Purpose of the Study:
- To review the progress in 3d transition metal-catalyzed enantioselective C-H functionalization.
- To highlight challenges and strategic solutions in the field.
- To provide a comprehensive overview of advancements up to March 2025.
Main Methods:
- Review of recent literature on 3d metal-catalyzed enantioselective C-H functionalization.
- Categorization of advancements by metal/ligand systems and reaction types.
- Analysis of inner-sphere and outer-sphere mechanisms.
Main Results:
- Significant progress has been made in 3d metal-catalyzed enantioselective C-H functionalization.
- Various metal/ligand systems have been developed for diverse C-H functionalization reactions.
- Key challenges have been addressed through innovative ligand design and reaction strategies.
Conclusions:
- 3d transition metals are becoming increasingly important catalysts for enantioselective C-H functionalization.
- Continued research in ligand design and mechanistic understanding will further advance the field.
- These catalytic systems offer powerful tools for both *de novo* synthesis and late-stage modification.
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