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Updated: Aug 6, 2026
07:12
Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells
Published on: September 9, 2021
The two faces of JAK-STAT
Qianying Lu1,2, Yingyi Zhang1,2
1School of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.
Elife
|July 16, 2026
Summary
A newly discovered signal may accelerate breast cancer growth but also enhance the immune system. This finding could lead to improved cancer immunotherapies.
Area of Science:
- Oncology
- Immunology
Background:
- Certain signals can promote tumor progression in breast cancer.
- The tumor microenvironment plays a critical role in immune evasion and response.
Purpose of the Study:
- To investigate the dual role of a specific signal in breast cancer cell growth and immune response.
- To explore the potential of this signal in enhancing cancer immunotherapy.
Main Methods:
- Utilized in vitro cell culture models of breast cancer.
- Analyzed immune cell activation and cytokine production in response to the signal.
- Assessed the impact of the signal on tumor growth in preclinical models.
Main Results:
- The signal was found to promote proliferation and survival of breast cancer cells.
- Concurrently, the signal significantly enhanced the activity of cytotoxic T lymphocytes.
- Combined treatment with the signal and immunotherapy showed reduced tumor burden.
Conclusions:
- The identified signal exhibits a dichotomous function, promoting cancer growth while simultaneously priming an anti-tumor immune response.
- Targeting this signal may represent a novel strategy to overcome resistance and improve the efficacy of current breast cancer immunotherapies.
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