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Published on: May 3, 2024
Pyroptosis: Molecular mechanisms and function
Amir Ajoolabady1, Altaf A Abdulkhaliq2, Johra Khan3
1National Clinical Research Center for Interventional Medicine, Shanghai, 200032, China.
Journal of Physiology and Biochemistry
|July 16, 2026
Summary
Pyroptosis is a regulated cell death process involving Gasdermin proteins forming pores, causing cell lysis and inflammation. This review details its mechanisms, triggers, and signaling pathways for deeper research insights.
Area of Science:
- Cellular biology
- Immunology
- Biochemistry
Background:
- Pyroptosis is a highly regulated lytic cell death.
- Gasdermin proteins execute pyroptosis via pore formation.
- Cell lysis releases pro-inflammatory mediators.
Purpose of the Study:
- To review the current understanding of pyroptosis mechanisms.
- To highlight recent findings on signaling pathways and regulation.
- To discuss emerging perspectives and implications for future research.
Main Methods:
- Literature review of pyroptosis.
- Summary of canonical and non-canonical pathways.
- Analysis of Gasdermin function and inflammasome activation.
Main Results:
- Pyroptosis involves Gasdermin N-terminal pore formation.
- Caspase activation (caspase-1 dependent or independent) triggers pyroptosis.
- Diverse stimuli activate distinct inflammasomes and caspases.
Conclusions:
- Pyroptosis is a critical inflammatory cell death pathway.
- Understanding its regulation is key for therapeutic development.
- Further research can uncover new insights and applications.
Keywords:
CaspasesCytokinesGasderminsInflammasomeInflammationMitochondriaMolecular mechanismsPlasma membrane poresPyroptosisMore Related Videos
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