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Association between Cognitive Function and Postoperative Stroke Following Off-Pump Coronary Artery Bypass Grafting
Chuanjie Yue1,2, Hao Cui1,2, Jinwei Zhang1,2
1Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Journal of Cardiovascular Translational Research
|July 16, 2026
Summary
Cognitive function, assessed by Montreal Cognitive Assessment (MoCA), is linked to postoperative stroke risk in patients undergoing coronary artery bypass grafting (CABG). Lower MoCA scores indicate a higher risk of stroke after CABG surgery.
Area of Science:
- Cardiology
- Neurology
- Cognitive Science
Background:
- Coronary artery bypass grafting (CABG) is a major cardiac surgery.
- Postoperative stroke is a significant complication following CABG.
- The role of preoperative cognitive function in predicting postoperative stroke requires further investigation.
Purpose of the Study:
- To investigate the association between preoperative cognitive function and the incidence of postoperative stroke in patients undergoing off-pump coronary artery bypass grafting (CABG).
Main Methods:
- A retrospective review of 1,932 patients who underwent off-pump CABG.
- Preoperative cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Pittsburgh Sleep Quality Index (PSQI), and Activities of Daily Living (ADL) scale.
- Statistical analysis, including stepwise regression, was used to identify predictors of postoperative stroke.
Main Results:
- A total of 34 patients (1.8%) experienced a postoperative stroke.
- Patients who developed a stroke had significantly lower preoperative MMSE and MoCA scores compared to those without stroke.
- Stepwise regression identified preoperative stroke history and lower MoCA scores as independent predictors of postoperative stroke.
Conclusions:
- Preoperative cognitive function, particularly as measured by the MoCA, is significantly associated with the risk of postoperative stroke in patients undergoing CABG.
- Cognitive assessment prior to CABG may help identify patients at higher risk for postoperative stroke.
- Further research is warranted to explore interventions to mitigate this risk.
