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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Association between adipose (pro)renin receptor expression and growth hormone deficiency in patients with
Noriyoshi Takano1, Yasufumi Seki2, Yuko Inoue1
1Division of Hormonal Medicine and Bioregulatory Science, Department of Medicine, Tokyo Women's Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Purpose:
Fat accumulation leads to obesity, which increases the risk of cardiovascular diseases. Recent studies have shown that adipose (pro)renin receptor ([P]RR) may play a role in fat accumulation, and we previously reported increased adipose (P)RR expression in growth hormone (GH) deficiency in mice; however, the association between human adipose (P)RR expression and GH deficiency remains unclear.
Methods:
In this prospective study, abdominal subcutaneous adipose tissue was collected during pituitary surgery in patients with non-functioning hypothalamic-pituitary masses, and the associations between adipose (P)RR mRNA expression, determined using reverse transcription-polymerase chain reaction, and GH deficiency and other clinical parameters were investigated.
Results:
Fifteen patients (5 craniopharyngioma, 4 non-functioning pituitary neuroendocrine tumor, 4 Rathke's cleft cyst, and 2 other diseases) (mean age, 53 ± 17 years; male sex, 3 [20%]; and mean body mass index [BMI], 24.8 ± 4.3 kg/m2; GH deficiency, 8 [53%]) were included. Adipose (P)RR mRNA expression was significantly higher in patients with GH deficiency (P = 0.009) compared to those without, but was not significantly associated with other pituitary functions. Adipose (P)RR mRNA expression was significantly correlated with BMI (r = 0.526, P = 0.044) and body fat mass (r = 0.728, P = 0.026, n = 9). GH deficiency was significantly associated with (P)RR mRNA after adjustment for obesity (β = 2.257, 95% CI: 0.367-4.417, P = 0.023).
Conclusion:
Adipose (P)RR expression may be increased in GH deficiency, suggesting the possible role of adipose (P)RR in fat accumulation in GH deficiency.
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