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Enhancing Safety With a Massive Transfusion Protocol for Patients With Cancer Experiencing Uncontrolled Hemorrhage
Colleen Villamin1, Jeff Beno2, Christine Rudzinski Raby3
1Colleen Villamin.
Clinical Journal of Oncology Nursing
|July 16, 2026
Summary
Oncology nurses can implement a massive transfusion protocol (MTP) to quickly manage hemorrhagic emergencies. This systematic approach ensures timely blood component transfusion, improving patient outcomes and reducing mortality.
Area of Science:
- Oncology Nursing
- Critical Care Medicine
- Hematology
Background:
- Hemorrhagic emergencies require timely and efficient responses from oncology nurses.
- Massive transfusion protocols (MTP) offer a systematic approach to managing uncontrolled hemorrhage.
- MTP utilizes a specific ratio of blood components to mimic whole blood resuscitation.
Purpose of the Study:
- To provide oncology nurses with a framework for implementing an MTP program.
- To enhance the response time to hemorrhagic emergencies in cancer patients.
- To reduce patient mortality associated with severe bleeding.
Main Methods:
- An institutional MTP program was developed and approved by a quality improvement board.
- The program established a clinical framework for MTP activation and defined team roles.
- Blood components (RBCs, plasma, platelets) were transfused in a 1:1:1 ratio.
- Program success was evaluated via quality assurance reviews focusing on efficiency and patient outcomes.
Main Results:
- MTP implementation ensured immediate availability of blood components in an optimal ratio.
- Interprofessional simulations prepared teams for rapid resuscitation during hemorrhagic events.
- The MTP program facilitated a structured and efficient response to critical bleeding.
Conclusions:
- Implementing an MTP program is crucial for oncology nurses managing hemorrhagic emergencies.
- Systematic training and protocol adherence improve patient resuscitation and outcomes.
- MTP programs enhance the capacity of cancer centers to handle critical bleeding events effectively.
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