Related Experiment Video
Updated: Aug 6, 2026
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Child Neurodevelopmental Outcomes After Late Preterm Hypoglycemia
Cynthia Gyamfi-Bannerman1, Jessica A de Voest, Alan T N Tita
1Columbia University, New York, New York; the University of California, San Diego, La Jolla, and Stanford University, Stanford, California; the George Washington University Biostatistics Center, Washington, DC; the University of Alabama at Birmingham, Birmingham, Alabama; the University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, the University of Texas Medical Branch, Galveston, and the University of Texas at Austin, Austin, Texas; the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; the University of North Carolina at Chapel Hill, Chapel Hill, and Duke University, Durham, North Carolina; Brown University, Providence, Rhode Island; the University of Utah Health Sciences Center, Salt Lake City, Utah; Eastern Virginia Medical School at Old Dominion University, Norfolk, Virginia; The Ohio State University, Columbus, and MetroHealth Medical Center-Case Western Reserve University, Cleveland, Ohio; the University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado; and Northwestern University, Chicago, Illinois.
Neonatal hypoglycemia in late preterm infants did not impact childhood neurodevelopmental outcomes. This study found no significant differences in cognitive, motor, social, or behavioral assessments between infants with and without hypoglycemia.
Area of Science:
- Neonatal Medicine
- Pediatric Neurology
- Developmental Pediatrics
Background:
- Hypoglycemia is a common neonatal complication, particularly in late preterm infants.
- Previous research suggests potential links between neonatal hypoglycemia and adverse neurodevelopmental outcomes.
- The impact of hypoglycemia on neurodevelopment in late preterm infants requires further investigation.
Purpose of the Study:
- To investigate the association between neonatal hypoglycemia and neurodevelopmental outcomes in children born to mothers at risk for late preterm delivery.
- To evaluate cognitive, motor, social, and behavioral development in children with a history of neonatal hypoglycemia.
Main Methods:
- Prospective follow-up study of children aged 6+ years from a multicenter randomized trial.
- Primary exposure: hypoglycemia (blood glucose <40 mg/dL within 24 hours of birth).
- Primary outcome: General Conceptual Ability (GCA) scores below 85 on the DAS-II; secondary outcomes included motor, social, and behavioral assessments.
Main Results:
- No significant difference in GCA scores below 85 between infants with and without hypoglycemia (15.9% vs 18.5%; aRR 1.03).
- No significant differences observed in secondary neurodevelopmental outcomes (motor, social, behavioral).
- Severity of hypoglycemia was not associated with any assessed outcomes.
Conclusions:
- Neonatal hypoglycemia was not associated with adverse neurodevelopmental outcomes in this cohort of predominantly late preterm infants.
- Findings suggest that transient hypoglycemia in late preterm neonates may not have long-term neurodevelopmental consequences.
Related Concept Videos
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:26Hypoglycemia
01:30Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
01:22Diabetes Mellitus: Type 2 and Gestational