Non-diabetic kidney disease in patients with diabetes undergoing native kidney biopsy
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Updated: Aug 6, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Rizza Antoinette So1, Susan Wan1, Amanda Siriwardana1,2,3
1Department of Renal Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Abstract:
Diabetes is often assumed to cause chronic kidney disease (CKD) in patients with diabetes, though non-diabetic pathology may coexist. We reviewed 84 patients with diabetes who underwent native kidney biopsy (2017-2023). Indications included active urinary sediment, nephrotic-range proteinuria and rapid renal decline. Non-diabetic pathology was found in 49% and mixed lesions in 21%, mainly IgA nephropathy, acute tubular necrosis and interstitial nephritis. Biopsy altered management in 23% of cases. These findings support the value of biopsy in patients with diabetes.
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