Mechanism-resolved structure-activity relationships in flavonoid antioxidants enabled by tail-assisted ESIPT and

Bifa Cao1, Xinru Zhang1, Qiao Zhou2

  • 1Basic Courses Department, Tianjin Sino-German University of Applied Sciences, Tianjin 300350, China.

Summary

This study introduces a novel tail-assisted proton transfer method to enhance antioxidant activity in flavonoids without consuming key hydroxyl groups. This design strategy improves antioxidant performance by leveraging folded molecular conformations and excited-state intramolecular proton transfer (ESIPT).

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