Related Experiment Video
Updated: Aug 6, 2026
06:55
Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents
Published on: October 26, 2016
Intestinal stent with polydopamine-enhanced sodium alginate/polyacrylamide hydrogel coating: Design, fabrication and
Zekun Su1, Wenyun Hou2, Xuhui Wang1
1School of Materials Science and Engineering, Dalian University of Technology, Dalian, 116024, PR China.
International Journal of Biological Macromolecules
|July 16, 2026
Summary
A novel 3D-printed intestinal stent coated with a special hydrogel effectively prevents tumor ingrowth and migration. This enhanced stent shows great promise for treating colorectal obstructions, improving patient outcomes.
Area of Science:
- Biomedical Engineering
- Materials Science
- Gastroenterology
Background:
- Endoscopic stent placement is crucial for malignant colorectal obstructions.
- Current stents face challenges like tumor ingrowth and migration, limiting long-term effectiveness.
Purpose of the Study:
- To develop and evaluate a novel 3D-printed intestinal stent with enhanced anti-tumor ingrowth and anti-migration properties.
- To improve the efficacy and durability of stents used in managing colorectal obstructions.
Main Methods:
- Fabrication of a 3D-printed flexible tubular intestinal stent.
- Coating the stent with a polydopamine-enhanced sodium alginate/polyacrylamide (SA/PAM) hydrogel (PSP hydrogel).
- Assessing the hydrogel's compressive strength, tissue adhesiveness, and stent's anti-migration force and flexibility.
Main Results:
- The PSP hydrogel coating significantly improved tissue adhesion (>10 kPa) and stent stability.
- The coated stent demonstrated excellent compressive strength (>45 kPa) and flexibility.
- Compared to uncoated stents, the hydrogel-coated stent exhibited a higher anti-migration force (>7 N) and reduced migration (<1 mm).
Conclusions:
- The novel PSP hydrogel-coated intestinal stent effectively inhibits tumor ingrowth and migration.
- The stent's enhanced mechanical properties and tissue adhesion show significant clinical potential for managing acute colorectal obstructions.
