Current evidence on radiofrequency denervation for chronic low back pain: a systematic review and meta-analysis
Kamilla My Thanh Lê Truong1,2, Esther Maas3, Mikkel Mylius Rasmussen4,2
1Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark kamillatruong@hotmail.com.
Objective:
To assess the effects of radiofrequency (RF) denervation for chronic low back pain (LBP) from facet joint, sacroiliac joint, discogenic and non-specific pain.
Design:
Systematic review and meta-analysis.
Data Sources:
We searched Medline, Embase, Cochrane Library, CINAHL, PsycINFO, ClinicalTrials.gov and WHO ICTRP up to 18 February 2025 for randomised controlled trials (RCTs).
Study Selection, Data Extraction And Synthesis:
Pairs of reviewers independently selected studies, extracted data and assessed risk of bias (Cochrane RoB 2). Meta-analyses with clinically homogeneous studies were performed and certainty of evidence was assessed using Grades of Recommendation, Assessment, Development and Evaluation.
Results:
55 RCTs (n=4394) were included; many outcomes were at some risk of bias. Low to moderate certainty evidence suggested small improvements in pain and function with RF denervation versus sham for facet joint pain, sacroiliac, discogenic and non-specific chronic LBP. None exceeded predefined minimally clinically important between-group differences, suggesting limited clinical relevance.
Conclusions:
RF denervation showed small improvements in pain and function compared with sham, steroid injection or standard care, but the effects did not reach clinically meaningful thresholds and the certainty of evidence was very low to moderate. Additional research is needed to clarify the effects of RF denervation and guide clinical decision-making.
Prospero Registration Number:
CRD42023460743.