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G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay
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Decoding functional specialization in G protein-coupled receptors (GPCRs) through evolution-guided residue profiling

Berkay Selçuk1,2, Gunnar Schulte3, Igor B Zhulin2

  • 1Molecular Biology, Genetics and Bioengineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Türkiye.

British Journal of Pharmacology
|July 17, 2026
PubMed
Summary

This study introduces a new evolutionary framework to classify G protein-coupled receptor (GPCR) positions. It distinguishes common residues (CRs) for stability and selective residues (SRs) for function, aiding in understanding GPCR diversity.

Keywords:
G protein‐coupled receptorsGPCRscommon residuesevolutionary conservationligand bindingorthologsparalogsreceptor diversificationselective residuestransducer coupling

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