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Updated: Aug 6, 2026
08:45
Establishment and Characterization of Patient-derived Gastric Organoids from Biopsies of Benign Gastric Body and Antral Epithelium
Published on: January 26, 2024
Reproducible Topographic Phenotypes and Three-Phase Anatomical Evolution of Gastric Intestinal Metaplasia
Chu-Po Chou1, Chen-Tu Wu2, Yih-Leong Chang2
1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Summary
Gastric intestinal metaplasia (IM) follows reproducible anatomical patterns and evolves through ordered topographic states, from the antrum to the corpus. This study clarifies IM progression and regression pathways.
Area of Science:
- Gastroenterology
- Endoscopic diagnostics
- Histopathology
Background:
- Gastric intestinal metaplasia (IM) is crucial for gastric cancer risk stratification.
- The anatomical patterns and evolutionary pathways of IM are not well-defined.
Purpose of the Study:
- To investigate whether gastric intestinal metaplasia (IM) exhibits reproducible topographic patterns.
- To determine if IM progresses and regresses through structured, ordered anatomical states.
Main Methods:
- Retrospective analysis of 3335 endoscopic examinations with Endoscopic Grading of Gastric Intestinal Metaplasia (EGGIM) scoring.
- Quantification of topographic coherence and severity gradients using statistical measures.
- Reconstruction of longitudinal IM trajectories in 486 patients with paired examinations.
Main Results:
- Cross-sectional analysis revealed highly reproducible topographic patterns of IM, with a consistent antrum-to-corpus severity gradient.
- Three distinct IM phenotypes were identified: antral-dominant, transitional, and corpus-involving.
- Longitudinal data showed that IM progression and regression mirrored an anatomical pathway, with distinct changes occurring in the antrum, transitional zone, and corpus based on score severity.
Conclusions:
- Gastric IM demonstrates reproducible topographic phenotypes.
- Findings support a three-phase anatomical framework for IM evolution, from the antrum through the transitional zone to the corpus.
- This framework aids in understanding IM progression and regression dynamics.
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