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Possibility to therapeutically exploit RGPR-p117 as a target in cancer cells

Masayoshi Yamaguchi1

  • 1Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, HI, USA.

Expert Opinion on Therapeutic Targets
|July 17, 2026
PubMed
Abstract

Insights

RGPR-p117, a transcription factor, shows promise in cancer therapy by suppressing tumor cell proliferation and enhancing tumor suppressors. Further research is needed to explore its therapeutic potential in clinical settings.

Area of Science:

  • Molecular biology
  • Cancer research
  • Gene therapy

Background:

  • RGPR-p117 is a transcription factor that binds to a specific DNA sequence in the regucalcin gene promoter.
  • Regucalcin is a known tumor suppressor gene.
  • RGPR-p117 plays a role in regulating gene transcription within the cell.

Purpose of the Study:

  • To investigate the therapeutic potential of RGPR-p117 in cancer treatment.
  • To explore the mechanisms by which RGPR-p117 affects cancer cell proliferation and gene expression.
  • To evaluate RGPR-p117 as a target for novel cancer therapies and gene therapy strategies.

Main Methods:

  • Identification of RGPR-p117 as a transcription factor.
  • Analysis of RGPR-p117's role in gene transcription, specifically the regucalcin gene.
  • Assessment of RGPR-p117's effects on cancer cell proliferation and expression of key proteins (e.g., Ras, PI3K, Akt, MAPK, mTOR, p53, Rb, p21) in vitro.
  • Investigation of RGPR-p117's nuclear translocation and its impact on gene expression.

Main Results:

  • RGPR-p117 enhances transcription of genes with a TTGGC motif, including the tumor suppressor regucalcin gene.
  • Overexpression of RGPR-p117 suppresses cancer cell proliferation.
  • RGPR-p117 decreases expression of growth-promoting proteins (Ras, PI3K, Akt, MAPK, mTOR) and increases tumor suppressors (p53, Rb, p21).

Conclusions:

  • RGPR-p117 demonstrates significant potential as a therapeutic target for cancer treatment.
  • Targeting RGPR-p117 nuclear translocation may offer a novel strategy for cancer suppression.
  • Further in vivo studies and clinical trials are necessary to validate these in vitro findings and address challenges for clinical application.
Keywords:
Cancer suppressionRGPR-p117SEC16Bregucalcintranscription factor

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