Association of Accelerometer-Derived Rest-Activity Rhythms and Sleep Health With Overactive Bladder: Depression as a...

Area of Science:

• Chronobiology
• Urology
• Sleep Medicine

Background:

• Overactive bladder (OAB) is a prevalent condition affecting quality of life.
• Rest-activity rhythms (RAR) and sleep are crucial for overall health.
• The relationship between sleep, circadian rhythms, and OAB requires further investigation.

Purpose of the Study:

• To investigate the association between accelerometer-derived rest-activity rhythms (RAR) and multidimensional sleep metrics with overactive bladder (OAB).
• To determine if depression mediates the relationship between RAR/sleep metrics and OAB.

Main Methods:

• Cross-sectional study of 6,603 adults from NHANES (2011-2014).
• OAB defined by Overactive Bladder Symptom Score ≥3.
• 7-day wrist accelerometry for RAR (IS, IV, RA) and sleep parameters.
• Patient Health Questionnaire-9 for depression assessment.
• Survey-weighted logistic regression and mediation analysis.

Main Results:

• OAB prevalence was 21.4%.
• Increased relative amplitude (RA) was associated with lower OAB odds (OR 0.83).
• Increased intradaily variability (IV) was associated with higher OAB odds (OR 1.05).
• Higher sleep efficiency and longer sleep duration were inversely associated with OAB.
• Depression partially mediated the RA-OAB relationship.

Conclusions:

• Weaker rest-activity rhythms and poorer sleep health are associated with higher OAB prevalence.
• Depression may partially explain the link between sleep/rhythm disturbances and OAB.
• Prospective studies are needed to validate these findings.