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LDSC regression-based heritability estimates can be biased when summary statistics are obtained from meta-analysis or

Rui Dong, Minghui Wang, Gao T Wang

    Biorxiv : the Preprint Server for Biology
    |July 17, 2026
    PubMed
    Summary

    Linkage disequilibrium score (LDSC) regression can underestimate heritability for complex traits. Using imputed variants or meta-analysis summary statistics may lead to biased results, highlighting the need for careful data selection in genetic studies.

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