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Updated: Aug 6, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
On the Increased and Decreased Connectivity of the Demented Human Brain
Abstract:
With major advances in cerebral imaging techniques, a large amount of data is available for studying the aging and demented brain. In this contribution, we apply the OASIS-3 dataset to identify small areas of human gray matter with higher or lower structural connectivity in dementia. As was anticipated, we have found that finer structures of the hippocampus and the temporal lobe have decreased connectivity in dementia. More surprisingly, the precuneus, the cuneus, and some finer structures of the insula, the paracentral lobule, and the precentral and paracentral gyri showed higher connectivity in dementia than in healthy subjects.
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