Logistic regression analysis of risk factors for abdominal adhesion during hyperthermic intraperitoneal chemotherapy...

The present study aimed to explore the risk factors for abdominal adhesion during hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer via logistic regression analysis. The present study is a retrospective analysis involving 165 patients with ovarian cancer treated at The Department of Gynecology, Shanghai First Maternity and Infant Hospital (Shanghai, China) from February 2021 to June 2023. All patients were treated with HIPEC or adjuvant therapy. During the treatment, the patients were divided into the control (n=61) and observation (n=104) groups according to the presence of abdominal adhesion. The results of the present study highlighted the notable role of monitoring biomarkers such as C-reactive protein and plasminogen activator inhibitor-1 in predicting the risk of abdominal adhesions in patients with ovarian cancer treated with HIPEC. By optimizing surgical techniques, controlling inflammatory reactions, adopting anti-adhesion strategies and implementing detailed preoperative assessment and preventive measures for patients undergoing HIPEC, the incidence of adhesions may be effectively reduced and treatment safety improved.