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TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
Published on: April 13, 2021
Dematiaceous Fungal Infections in Kidney Transplant Recipients - Case Series
Chilaka Rajesh1,2, Madhurima Ponmar1, Athul Thomas1,2
1Departments of Nephrology, Pathology, Christian Medical College, Vellore, Tamil Nadu, India.
Indian Journal of Transplantation
|July 17, 2026
Summary
Dematiaceous fungal infections are rare but serious in kidney transplant recipients. Early diagnosis and treatment with antifungals are crucial for successful outcomes and preventing recurrence.
Area of Science:
- Nephrology
- Mycology
- Infectious Diseases
Background:
- Kidney transplant recipients are susceptible to opportunistic infections.
- Dematiaceous fungi cause phaeohyphomycosis, a rare but significant infection.
Purpose of the Study:
- To analyze the clinical characteristics and outcomes of dematiaceous fungal infections in kidney transplant recipients.
- To emphasize early diagnosis and management strategies.
Main Methods:
- Retrospective, single-center study.
- Analysis of 1,041 kidney transplant recipients from 2010-2022.
- Review of clinical data, diagnosis via culture and histopathology.
Main Results:
- Dematiaceous fungi caused 8.6% of major fungal infections (n=6).
- Infections presented as skin lesions, arthritis, or sinusitis 3.43 years post-transplant.
- Long-term itraconazole therapy was effective, with low recurrence rates.
Conclusions:
- Heightened clinical suspicion is needed for atypical lesions in transplant recipients.
- Early microbiological and histopathological assessment is vital.
- Prompt antifungal therapy and surgical intervention improve outcomes.
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