Ovary Preservation for Cervical Clear Cell Adenocarcinoma in an 8-Year-Old Girl: A Novel Approach

Cervical clear cell adenocarcinoma is a rare malignancy in adolescents and young girls. Since the prescription of diethylstilbestrol (DES) was banned in 1971, only 11 cases have been reported in girls under 10 years in the literature. However, treatment with ovary preservation has not been reported. Here, we report an 8-year-old prepubertal girl without a history of exposure to DES who was diagnosed with cervical clear cell adenocarcinoma. Hysterectomy and unilateral oophorectomy were performed. The remaining ovary was transposed to the left iliac fossa to preserve ovarian function for the future. Additionally, ovarian cortical tissue from the removed ovary was cryopreserved. Chemotherapy, including paclitaxel and carboplatin, was started after surgery for four cycles via an implantable venous access port. Additionally, genetic analysis did not identify any known gene mutations in the tumour tissue.