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Protein engineering: Status report
Hui-Wang Ai1, Frances H Arnold2, Doug Barrick3
1Center for Membrane and Cell Physiology, Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia, 22908, United States.
Protein Engineering, Design & Selection : PEDS
|July 17, 2026
Summary
Protein engineering is rapidly advancing, integrating computational and experimental methods to create novel proteins. This field is entering a golden age, despite ongoing challenges in design and application.
Area of Science:
- Protein engineering is a rapidly advancing scientific discipline.
Background:
- It integrates computational, molecular biology, structure-guided, evolutionary, and synthetic approaches.
- The field has historical foundations and recent advances, with growing machine learning and artificial intelligence influence.
Purpose of the Study:
- To provide a timely snapshot of the protein engineering field.
- To highlight core methodologies and major application domains.
Main Methods:
- The report is organized into eight thematic areas.
- Contributions from experts across these areas.
Main Results:
- Protein engineering is entering a golden age with accelerating progress.
- Significant challenges in design, screening, and real-world application remain.
Conclusions:
- Continued integration of computational and experimental strategies will accelerate impact.
- Protein engineering will expand across therapeutics, diagnostics, industrial chemistry, and materials science.
