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Updated: Aug 6, 2026
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Application of Mid-Pancreatectomy with End-to-End Anastomosis in Pancreatic Benign Tumors
Published on: February 9, 2024
Actual 10-year survival after total pancreatectomy: a multicenter study
Yusuke Kawachi1, Jun Sakata2, Tomohiro Katada3
1Division of Digestive and General Surgery, Niigata University Graduate School of Medicine, Dentistry, and Health Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951- 8510, Japan.
Langenbeck'S Archives of Surgery
|July 17, 2026
Summary
Long-term outcomes after total pancreatectomy (TP) are mainly driven by cancer factors. Actual 10-year survivors often had less aggressive tumors and avoided extensive surgery, with most deaths linked to disease progression.
Area of Science:
- Surgical Oncology
- Gastroenterology
- Clinical Outcomes Research
Background:
- Total pancreatectomy (TP) is increasingly performed due to improved short-term results.
- Limited data exist on the long-term outcomes and survival patterns following TP.
Purpose of the Study:
- To evaluate the long-term outcomes of patients undergoing TP.
- To identify factors influencing survival and causes of death in 10-year survivors of TP.
Main Methods:
- Retrospective analysis of patients who underwent elective TP and were followed for at least 10 years or until death.
- Classification of patients into 10-year survivors and non-survivors.
- Analysis of clinicopathological characteristics, survival rates, and causes of mortality.
Main Results:
- The actual 5- and 10-year overall survival rates were 28.6% and 18.4%, respectively.
- Nine patients (18.4%) achieved 10-year survival, predominantly those without vascular resection, multivisceral resection, or R1/2 resection.
- Pancreatic ductal adenocarcinoma was the most common indication (57.1%); most deaths were due to disease progression within 5 years.
Conclusions:
- Long-term outcomes after TP are significantly influenced by oncological factors.
- Favorable tumor characteristics and avoidance of extended resection are associated with 10-year survival.
- Findings highlight the importance of patient selection and tumor biology in predicting long-term success after TP.
