Related Experiment Video

Updated: Aug 6, 2026

Visualization and Quantitative Analysis of Genotoxin-Induced PARP1/PARP2 Activation in Cells Using a Fluorescent Fusion Protein-Based Reporter
07:53

Visualization and Quantitative Analysis of Genotoxin-Induced PARP1/PARP2 Activation in Cells Using a Fluorescent Fusion Protein-Based Reporter

Published on: April 17, 2026

Targeting p300 Reverses Acidic Microenvironment-Induced PARP Inhibitor Resistance

Kaixin Cheng1, Hao Nie1, Wei Zhou2

  • 1The University of Texas MD Anderson Cancer Center Houston, TX United States.

Cancer Research
|July 17, 2026
PubMed
Summary

Tumor acidosis promotes resistance to Poly(ADP-ribose) polymerase inhibitors (PARPi) in ovarian cancer by activating p300. Inhibiting p300 may overcome this resistance, improving PARPi efficacy.

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