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Inhibitory effect of 17β-estradiol on the THIK-1 channel

Michihiro Tateyama1,2, Yoshihiro Kubo1,2

  • 1Division of Biophysics & Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, Okazaki, Japan.

Plos One
|July 17, 2026
PubMed
Summary

Estradiol inhibits the THIK-1 potassium channel, crucial for immune cells. Specific mutations reveal that the channel's "pond" region is key for this inhibition, with implications for THIK-1 variants.

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