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Published on: July 24, 2013
Rethinking aging biomarkers in HIV: from measures to meaning
Ekta Singh1, Alan L Landay1,2, Matthew L Mendoza3,4
1Department of Internal Medicine.
Current Opinion in HIV and AIDS
|July 17, 2026
Summary
People with HIV experience accelerated aging and related health issues. Biomarkers are emerging to track this complex aging process, aiding in better risk assessment and treatment monitoring for individuals with HIV.
Area of Science:
- Gerontology
- Immunology
- Biomarker Discovery
Background:
- People with HIV (PWH) on antiretroviral therapy still face significant age-related diseases and multiple health conditions.
- HIV-associated aging is viewed as a systemic breakdown in resilience and regulation.
Purpose of the Study:
- To review HIV-associated aging as a systems-level dysregulation.
- To evaluate biomarker strategies for capturing the biological and clinical diversity of aging in PWH.
Main Methods:
- Review of recent evidence on aging pathways in HIV.
- Analysis of composite biomarker approaches for various health outcomes.
- Evaluation of large cohort studies, risk models, and intervention trials.
Main Results:
- Aging in HIV involves complex immune, metabolic, regenerative, and inter-organ interactions.
- Composite biomarkers integrating molecular, physiological, and functional data are used for cardiovascular, neurocognitive, and physical outcomes.
- Biomarkers show clinical relevance and potential as endpoints in gerotherapeutic studies.
Conclusions:
- No single biomarker is sufficient for assessing HIV-associated aging.
- Future advancements require multimodal biomarkers integrating biological and functional aspects.
- AI and machine learning will enhance risk stratification and monitoring of interventions for PWH.
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