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Comprehensive Risk Factor Profiles, Coronary Heart Disease, and Life Expectancy in Cancer Survivors
Yang-Wei Cai1, Chuan-Rui Zeng2, Mao-Xiong Wu2
1Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China; Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address: https://twitter.com/cai_yangwe15561.
JACC. Advances
|July 17, 2026
Summary
Managing multiple risk factors significantly lowers coronary heart disease (CHD) and cardiovascular disease (CVD) mortality in cancer survivors. Optimizing these factors improves long-term survival and life expectancy.
Area of Science:
- Cardiovascular Health
- Oncology Survivorship
- Preventive Medicine
Background:
- Cancer survivors face a nearly twofold increased risk of coronary heart disease (CHD) compared to the general population.
- This elevated risk underscores the need for targeted cardiovascular risk management strategies in cancer survivorship care.
Purpose of the Study:
- To investigate the association between the control of multiple risk factors and the excess CHD risk in cancer survivors.
- To determine the impact of joint risk factor control on residual life expectancy among cancer survivors.
Main Methods:
- Analysis of 14,557 cancer survivors and 58,228 matched controls from the UK Biobank.
- Risk factor control assessed across nine domains: blood pressure, BMI, LDL cholesterol, HbA1c, renal function, smoking, physical activity, diet, and sleep.
- Cox proportional hazards and flexible parametric survival models used to evaluate CHD, MI, CVD mortality, and life expectancy.
Main Results:
- Each additional controlled risk factor was linked to significantly reduced risks of CHD, myocardial infarction (MI), and CVD mortality.
- Individuals with six or more controlled risk factors exhibited the lowest cardiovascular event rates.
- Greater risk factor control correlated with increased residual life expectancy at age 50.
Conclusions:
- Joint control of modifiable risk factors is associated with decreased CHD, MI, and CVD mortality in cancer survivors.
- Comprehensive risk factor management is crucial for cardiovascular risk reduction in cardio-oncology survivorship care.
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