Chemerin Promotes Obesity-Accelerated Orthodontic Tooth Movement by Activating IRE1α-Dependent ER Stress in PDL...

Area of Science:

• Periodontal biology
• Endocrinology
• Biomedical engineering

Background:

• Obesity is linked to accelerated orthodontic tooth movement (OTM).
• Chemerin, a adipokine, is upregulated in obesity and may influence OTM.
• Understanding chemerin's role is crucial for managing OTM in obese individuals.

Purpose of the Study:

• To investigate the role of obesity-associated chemerin upregulation in OTM.
• To elucidate the underlying mechanisms, including endoplasmic reticulum (ER) stress.
• To identify cellular sources of chemerin in the periodontium.

Main Methods:

• In vivo (obese mice) and in vitro (human periodontal ligament fibroblasts) models of OTM.
• Evaluation of chemerin expression and manipulation (overexpression/silencing) of Rarres2 (gene encoding chemerin).
• Single-cell RNA sequencing reanalysis and bioinformatic analysis to identify cellular sources and mechanisms.

Main Results:

• Chemerin expression was elevated in OTM, particularly under obese conditions.
• Rarres2 overexpression aggravated periodontal inflammation and accelerated OTM in obese mice.
• Chemerin promoted IRE1α-mediated ER stress in periodontal ligament cells and tissues.

Conclusions:

• Chemerin exacerbates periodontal inflammation and accelerates obesity-related OTM.
• This occurs through the promotion of IRE1α-mediated endoplasmic reticulum stress.
• Targeting this pathway offers potential therapeutic strategies for obesity-related OTM.