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Updated: Aug 6, 2026

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse
Published on: August 7, 2013
The enteric nervous system: A neuroimmune conductor regulating intestinal homeostasis and inflammation
1State Key Laboratory of Gene Expression, School of Medicine, School of Life Science, Westlake University, Hangzhou, Zhejiang 310024, China; Westlake Laboratory of Life Sciences and Biomedicine; Hangzhou, Zhejiang 310024, China.
Abstract:
The gastrointestinal tract is densely innervated by the enteric nervous system (ENS), a complex neural network that regulates intestinal physiology. Emerging advances highlight the essential contributions of ENS to immune homeostasis and inflammatory responses within the gut. This review synthesizes current understanding of the interactions between the intrinsic enteric neurons and various intestinal immune cells, epithelium cells and the microbiome. We also discuss recent technological developments that enhance our ability to dissect the immunomodulatory functions of enteric neurons. Elucidating these complex communication pathways is critical for advancing our understanding of gut function and mucosal inflammation, and for developing novel therapeutic strategies for gastrointestinal disorders.
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