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Clinical and bacteriological studies with clindamycin.

A M Geddes, F A Bridgwater, D N Williams

    British Medical Journal
    |June 20, 1970
    PubMed
    Summary
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    Clindamycin, a lincomycin analogue, showed high effectiveness in treating 50 patients, with 44 responding well. This antibiotic is effective against recent staphylococci strains, with rare gastrointestinal issues but some skin rashes observed.

    Area of Science:

    • Medical Microbiology
    • Clinical Pharmacology
    • Infectious Diseases

    Background:

    • Clindamycin is a lincosamide antibiotic, a chemical analogue of lincomycin.
    • Antibiotic resistance in staphylococcal infections is a growing concern.
    • Evaluating the efficacy and safety of clindamycin is crucial for clinical practice.

    Purpose of the Study:

    • To assess the clinical efficacy of clindamycin in a patient cohort.
    • To document the incidence and nature of side effects associated with clindamycin treatment.
    • To determine the susceptibility of recent staphylococcal isolates to clindamycin.

    Main Methods:

    • A cohort of fifty patients received clindamycin treatment.
    • Treatment response was evaluated based on clinical outcomes.

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  • Adverse events, including gastrointestinal effects and rashes, were recorded.
  • Antimicrobial susceptibility testing was performed on isolated staphylococci.

    • Main Results:

    • Forty-four out of fifty patients (88%) demonstrated a satisfactory response to clindamycin.
    • Gastrointestinal side effects were infrequent.
    • Five patients (10%) experienced skin rashes as an adverse event.
    • Most recently isolated staphylococci strains were found to be sensitive to clindamycin.

    Conclusions:

    • Clindamycin is a highly effective antibiotic with a good response rate in patients.
    • The antibiotic is generally well-tolerated, with a low incidence of gastrointestinal side effects.
    • Clindamycin remains a viable treatment option for infections caused by sensitive staphylococcal strains.