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Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species
08:31

Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species

Published on: October 15, 2013

Central nervous system infection due to Burkholderia pseudomallei: a multicenter, 15-year retrospective study from

Hua Wu1, Yujuan Long2, Qinlei Cai3

  • 1Department of Clinical Laboratory, Hainan Women and Children's Medical Center, Hainan Medical University School of Pediatrics, Haikou, China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|July 17, 2026
PubMed
Abstract

Insights

Central nervous system (CNS) melioidosis has a high mortality rate, particularly in diabetic males. Early diagnosis and prompt treatment with antibiotics and surgery are crucial for improving patient outcomes.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Microbiology

Background:

  • Melioidosis is an endemic infectious disease in Southeast Asia and Northern Australia.
  • Central nervous system (CNS) melioidosis is a rare but highly fatal complication.
  • Understanding its clinical profile is vital for effective management.

Purpose of the Study:

  • To determine the clinical characteristics of CNS melioidosis in Hainan, China.
  • To identify factors influencing mortality and prognosis.
  • To provide insights for improved diagnosis and treatment strategies.

Main Methods:

  • A multicenter retrospective analysis of 42 CNS melioidosis cases from 2010-2025 in Hainan, China.
  • Collection and analysis of demographic and clinical data.
  • Antimicrobial susceptibility testing and comparative statistical analysis between survivors and non-survivors.

Main Results:

  • The mortality rate for CNS melioidosis was 31.0% (13/42).
  • Intracranial involvement was common (76.2%), with diabetes (59.5%) as the predominant risk factor.
  • Fever, headache, and altered consciousness were frequent symptoms; ceftazidime or trimethoprim-sulfamethoxazole and surgical intervention were associated with lower mortality.

Conclusions:

  • CNS melioidosis in Hainan predominantly affects diabetic males, often presenting with nonspecific neurological symptoms.
  • Delayed diagnosis due to non-specific symptoms contributes to high mortality.
  • Enhanced clinical vigilance, multi-specimen cultures, and timely treatment are essential for better prognoses.
Keywords:
Burkholderia pseudomalleiCentral nervous system infectionsMelioidosis

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