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Ampakine-Hypoxia pairing reveals a novel NMDA-dependent respiratory neuroplasticity

Pauline Michel-Flutot1, Kun-Ze Lee2,3, Stéphane Vinit1

  • 1Université Paris-Saclay, UVSQ, Inserm U1357, IMPROVE, 78000 Versailles, France.

Function (Oxford, England)
|July 17, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Ampakine-hypoxia pairingNMDA-dependent plasticityphrenic motor facilitationrespiratory motor controlspinal cord injury rehabilitationsynaptic plasticity

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Physiology of Respiration II: Neurogenic Control of Respiration01:22

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The neurogenic control of respiration coordinates various neural networks and pathways to regulate breathing rate and depth, meeting the body's oxygen and carbon dioxide exchange requirements. This system adapts to physiological and environmental conditions, ensuring optimal breathing patterns.
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
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Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
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