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Severe cytotoxic edema after CAR-T cell therapy for acute lymphoblastic leukemia

Victor Rebelo Procaci1,2, Maria Luiza Lacerda3, Luis Filipe de Souza Godoy3

  • 1Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Neurologia, Setor de Neurologia Geral e Ataxias, São Paulo SP, Brazil.

Arquivos De Neuro-Psiquiatria
|July 17, 2026
PubMed
Abstract

No abstract available in PubMed .

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Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...

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