Clinical features and intraocular lens material properties for posterior capsule opacification risk prediction

Posterior Capsule Opacification (PCO) remains a prevalent long-term complication following surgery for cataract, the world's primary blinding disease, significantly compromising visual outcomes. Although intraocular lens (IOL) material is a recognized risk factor, large-scale datasets linking granular material properties with longitudinal clinical outcomes remain scarce. Here, we present a real-world dataset comprising clinical records from 16,970 patients (22,709 eyes) who underwent cataract surgery at the Eye Center of the Second Affiliated Hospital of Zhejiang University School of Medicine in China between January 2019 and December 2022, with follow-up extending to May 2025. The dataset integrates patient demographics, systemic and ocular comorbidities, and surgical parameters. Crucially, these clinical variables are augmented with detailed IOL physicochemical specifications, covering both macroscopic design features and constituent chemical monomers (e.g., HEMA, EA). All records were extracted from electronic health records, rigorously anonymized, and technically validated against established epidemiological patterns. This resource provides a foundation for investigating the multifactorial determinants of PCO, facilitating analyses ranging from clinical risk assessment to the evaluation of biomaterial biocompatibility.