Association between the CCR2-V64I polymorphism and cancer susceptibility: a meta-analysis of 20 case-control studies

According to previous studies, the CCR2-V64I polymorphism has been associated with susceptibility to various cancers, yet this relationship remains controversial. To systematically evaluate this association, we conducted a meta-analysis to summarize and validate the available evidence. We comprehensively searched the PubMed, Embase, and Cochrane Library databases and ultimately included 20 case-control studies based on relevance and quality, comprising 4438 cases and 4874 controls. The association strength was analyzed using odds ratios and 95% confidence intervals. Overall analysis revealed a potential association between the CCR2-V64I polymorphism and cancer risk. Subgroup analyses by cancer type indicated that this polymorphism served as a risk factor for oral and bladder cancers, while exerting a protective effect against cervical cancer. Further organ-system-based stratification suggested that this polymorphism was associated with an increased risk of urinary system cancers and head and neck cancers. The results of ethnic subgroup analyses indicated that this polymorphism might be associated with a significantly elevated cancer risk in Caucasian populations. These findings demonstrated that the CCR2-V64I polymorphism may significantly influence cancer susceptibility.