Related Experiment Video
Updated: Aug 6, 2026
05:58
Measuring Relative Insulin Secretion using a Co-Secreted Luciferase Surrogate
Published on: June 25, 2019
Nutrient and non-nutrient regulators of insulin secretion
Jelena Kolic1,2, Noor Assaf3, James D Johnson4
1Department of Physiology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada. jkolic@ualberta.ca.
Nature Reviews. Endocrinology
|July 17, 2026
Summary
Insulin secretion by pancreatic beta-cells is regulated by glucose and other factors like nutrients and lifestyle. Understanding these complex mechanisms is key for managing metabolic diseases like diabetes mellitus.
Area of Science:
- Endocrinology
- Metabolic Health
- Cell Biology
Background:
- Insulin secretion from pancreatic beta-cells is vital for glucose homeostasis.
- Glucose is a primary stimulus, but other factors also influence insulin release.
Purpose of the Study:
- To review the multifactorial regulation of insulin secretion.
- To highlight factors beyond glucose influencing insulin release and their role in metabolic health.
Main Methods:
- Literature review integrating human in vitro and preclinical model data.
- Discussion of molecular mechanisms, physiological dynamics, and pathophysiological significance.
Main Results:
- Insulin secretion is modulated by nutrients (amino acids, fatty acids), non-nutrient factors, and lifestyle.
- Dysregulation contributes to hyperinsulinaemia, insulin resistance, and metabolic diseases.
Conclusions:
- Insulin secretion is complex, influenced by numerous factors.
- Further research, especially in human models, is needed to develop strategies for diabetes mellitus prevention and management.
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