Related Experiment Video
Updated: Aug 6, 2026

DNA Fingerprinting of Mycobacterium leprae Strains Using Variable Number Tandem Repeat (VNTR) - Fragment Length Analysis (FLA)
Published on: July 15, 2011
Ancient Mycobacterium leprae genomes reveal a potential origin and dispersal of the ancestral Branch 0
Shuang Fu1, Xingyu Lin2, Ying Nie3
1Key Laboratory for Paleogenetics and Molecular Evolution of Jilin Province, School of Life Sciences, Jilin University, Changchun, China.
Abstract:
Although previous studies have examined numerous ancient Mycobacterium leprae genomes, the available strains remain concentrated in western Eurasia. Ancient genomes from eastern Eurasia have remained virtually unexplored, limiting our ability to reconstruct the evolutionary history of M. leprae. In this study, we report the first two ancient M. leprae genomes recovered from this region. Phylogenetic analyses place both genomes within the ancestral Branch 0, and the observed phylogeographical patterns are consistent with the hypothesis that this lineage originated in southern East Asia. Together, these findings expand the known ancient genomic diversity of M. leprae and suggest that population movements across the Tianshan region may have contributed to its wider dissemination.
More Related Videos
10:32Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
Published on: March 23, 2014
08:34Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes
Published on: September 27, 2018
Related Concept Videos
Evolution of Microbial Genome
Bacterial Phylum Spirochaetes
Retroviruses
Evolution of New Traits in Microbes
Microbial Phylogeny
Tuberculosis